Therapeutic effects of shibashin misena® against fine-dust-induced pulmonary disorders in mice - 14/03/20
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Abstract |
Introduction |
In recent decades, fine-dust particulate matter (FM) has become a potential health hazard, causing various pathological respiratory disorders around the world. Inflammation induced by FM is regarded as a major cause of respiratory disorder in humans. The purpose of this study was to evaluate the therapeutic efficacy of Shibashin Misena®, a functional food composed of various bioactive ingredients, on FM-induced respiratory disorders in mice.
Materials and methods |
Briefly, 40 mice were divided equally into four groups: normal controls (NC); FM-induced control group (FC); FM group treated with Shibashin Misena® 0.1 mL/head/day (FM0.1); FM group treated with Shibashin Misena® 0.2 mL/head/day (FM0.2).
Results |
FM significantly induced TNF-α, IL-17A, IL-1β, and TGF-β in bronchoalveolar lavage fluid (BALF) collected from the FM mice. Compared with FC, Shibashin Misena® decreased TNF-α, IL-17A, and IL-1β levels in BALF, and histopathologic evaluations revealed that Shibashin Misena® treatment significantly reduced inflammatory-cell infiltration and fibrosis related collagen deposition in lung tissue.
Conclusion |
This study demonstrated that Shibashin Misena® decreased FM-induced inflammation and fibrosis in lung tissue. Thus, Shibashin Misena® could be an effective supplement to prevent or improve FM-induced pulmonary disorders.
El texto completo de este artículo está disponible en PDF.Keywords : Fine-dust particulate matter, Shibashin misena®, Inflammation, Fibrosis, Pulmonary disorders
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Vol 125
Artículo 110018- mai 2020 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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