Association between CNTF Polymorphisms and Adiposity Markers in European Adolescents - 20/03/20

Doi : 10.1016/j.jpeds.2019.12.036

Jose M. Pascual-Gamarra, PhD ^1,^2,^⁎^{^{∗
Contributed equally to this work.}} , Diego F. Salazar-Tortosa, PhD ^3,^{^{∗
Contributed equally to this work.}}, Idoia Labayen, PhD ⁴, Azahara I. Rupérez, PhD ⁵, Laura Censi, PhD ⁶, Laurent Béghin, PhD ⁷, Nathalie Michels, PhD ⁸, Marcela Gonzalez-Gross, PhD ⁹, Yannis Manios, PhD ¹⁰, Christina-Paulina Lambrinou, PhD ¹⁰, Luis A. Moreno, PhD ⁵, Aline Meirhaeghe, PhD ¹¹, Manuel J. Castillo, PhD ², Jonatan R. Ruiz, PhD ^12,¹³
¹ PROFITH (Promoting Fitness and Health Through Physical Activity) Research Group, Faculty of Medicine, Department of Physiology, University of Granada, Granada, Spain
² Department of Physiology, Faculty of Medicine, University of Granada, Granada, Spain
³ Department of Ecology, Faculty of Sciences, University of Granada, Granada, Spain
⁴ Department of Health Sciences, Public University of Navarra, Pamplona, Spain
⁵ GENUD (Growth, Exercise, Nutrition and Development) Research Group, Department of Health and Human Performance, School of Health Sciences, University of Zaragoza, Zaragoza, Spain
⁶ Council for Agricultural Research and Economics, Research Center for Food and Nutrition, Rome, Italy
⁷ Research Center, Faculty of Medicine, Lille Inflammation Research International Center, Lille Cedex, France
⁸ Department of Public Health and Primary Care, Ghent University, Ghent, Belgium
⁹ Department of Health and Human Performance, Universidad Politécnica de Madrid, Madrid, Spain
¹⁰ Department of Nutrition and Dietetics, Harokopio University of Athens, Greece
¹¹ INSERM, Institut Pasteur de Lille, University of Lille, Lille, France
¹² PROFITH Research Group, Faculty of Sport Sciences, Department of Physical Education and Sport, Sport and Health University Research Institute, University of Granada, Granada, Spain
¹³ Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden

^∗Reprint requests: Jose Miguel Pascual-Gamarra, Department of Physiology, Faculty of Medicine, University of Granada, Avda de la Investigación 11, 18016 Granada, Spain.Department of PhysiologyFaculty of MedicineUniversity of GranadaAvda de la Investigación 11Granada18016Spain

Abstract

Objective

To examine the association between polymorphisms of the ciliary neurotrophic factor gene (CNTF) and total and central adiposity markers in adolescents.

Study design

This cross-sectional study involved 1057 European adolescents aged 12-18 years enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. Five polymorphisms of CNTF were genotyped, and the weight, height, waist and hip circumference, and triceps and subscapular skinfold thickness of the subjects were measured and recorded.

Results

The T allele of rs2509914, the C allele of rs2515363, and the G allele of rs2515362 were significantly associated (after Bonferroni correction) with higher values for several adiposity markers under different inheritance models. The CNTF CCGGA haplotype (rs2509914, rs17489568, rs2515363 rs1800169, and rs2515362) was also significantly associated with lower body mass index, waist circumference, waist/height ratio, and waist/hip ratio values compared with the TCCGG haplotype under several inheritance models.

Conclusions

Three polymorphisms—rs2509914, rs2515363, and rs2515362—and the CCGGA haplotype of CNTF were significantly associated with adiposity in European adolescents. These results suggest the potential role of CTNF in the development of obesity-related phenotypes.

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Abbreviations : BMI, CNTF, FDR, HWE, SNP

Esquema

The HELENA Study is supported by contract FOOD-CT-2005-007034 from the European Community Sixth RTD Framework Programme. The study was supported by the Spanish Ministry of Education (Grants FPU16/02127 and FPU13/03410); Redes Temáticas de Investigación Cooperativa (Grant Red SAMID RD16/0022); University of Granada Plan Propio de Investigación 2016 (Excellence Actions: Unit of Excellence on Exercise and Health); Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades; and European Regional Development Fund (SOMM17/6107/UGR). The authors declare no conflicts of interest.

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Vol 219

P. 23 - avril 2020 Regresar al número

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Association between CNTF Polymorphisms and Adiposity Markers in European Adolescents - 20/03/20

Abstract

Objective

Study design

Results

Conclusions

Esquema

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