Reflectance confocal microscopy : Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathologic correlates of key confocal criteria, and diagnostic algorithms - 05/12/20

Doi : 10.1016/j.jaad.2020.05.154

Neda Shahriari, MD ^a,^⁎ , Jane M. Grant-Kels, MD ^a,^b, Harold Rabinovitz, MD ^c,^d, Margaret Oliviero, NP ^c, Alon Scope, MD ^e,^f
^a Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut
^b Department of Dermatology, University of Florida, Gainesville, Florida
^c Skin and Cancer Associates, Plantation, Florida
^d Dermatology Department, Medical College of Georgia at Augusta University, Augusta, Georgia
^e The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
^f Dermatology Service, Memorial Sloan-Kettering Center, New York, New York

^∗Reprint requests: Neda Shahriari, MD, Department of Dermatology, University of Connecticut Health Center, 21 South Rd, Farmington, CT 06032.Department of DermatologyUniversity of Connecticut Health Center21 South RdFarmingtonCT06032

Abstract

Reflectance confocal microscopy (RCM) is a high-resolution, noninvasive tool that is currently approved by the US Food and Drug Administration for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing unnecessary biopsy procedures in patients with benign lesions. The second article in this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers—melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions—melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus–like keratosis, and sebaceous hyperplasia. We also correlate the dermoscopic and histopathologic findings with the RCM features.

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Key words : BCC, benign neoplasms, diagnostic algorithms, melanoma, nevi, reflectance confocal microscopy, SCC

Abbreviations used : AK, BCC, DEJ, DN, LM, LMM, LPLK, RCM, SCC, SK

Esquema

Benign nonmelanocytic lesions

Solar lentigo

Seborrheic keratosis

Lichen planus–like keratosis

Sebaceous hyperplasia

Malignant nonmelanocytic lesions

BCC

Actinic keratosis

Squamous cell carcinoma

Benign melanocytic nevi

Common nevi

Dysplastic (atypical) nevi

Spitz nevi

Malignant melanoma

	Supported by the Israel Science Foundation (ISF-1546-16).
	Dr Rabinowitz is a speaker for Caliber and has received equipment in the past. Ms Oliviero is a speaker and consultant for Caliber ID. Drs Shahriari, Grant-Kels, and Scope have no conflicts of interest to declare.
	Date of release: January 2021.
	Expiration date: January 2024.