Codonopis bulleynana Forest ex Diels (cbFeD) effectively attenuates hepatic fibrosis in CCl4-induced fibrotic mice model - 19/12/20
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Graphical abstract |
Highlights |
• | Water extract from cbFeD contains hundreds of chemicals which enriched in organic acid and its derivatives, flavone, amino acid derivatives, nucleotide and its derivatives, carbohydrates etc. |
• | Water extract of cbFeD showed hepatoprotective activities and attenuated liver fibrogenesis against carbon tetrachloride (CCl4)-induced chronic liver injury. |
• | cbFeD suppressed the intrahepatic recruitment of inflammatory cells and inhibited the activation of hepatic stellate cells (HSCs). |
Abstract |
The root of Codonopis bulleynana Forest ex Diels (cbFeD), a tonic food widely used in Yunnan Province of China, was found to have a wide range of pharmacological effects. The present study was designed to investigate the anti-fibrotic effect of water extracts of cbFeD in chronic liver injury mice model induced by carbon tetrachloride (CCl4) and to explore its underlying mechanisms. Phytochemical analysis revealed multiple components were present in the water extract of cbFeD and the compounds were mostly enriched in organic acid and its derivatives, flavone, amino acid derivatives, nucleotide and its derivatives, carbohydrates etc. Treatment with cbFeD significantly attenuated liver injury and fibrosis in CCl4-administered mice evidenced by improved liver histology, ameliorated apoptosis of hepatocytes, and decreased transaminase levels in the serum. Decreased activities of superoxide dismutase (SOD) and catalase (CAT) were markedly reversed upon treatment with cbFeD while levels of malondialdehyde (MDA) and glutathione (GSH) were significantly restored towards normal values. cbFeD also suppressed intrahepatic inflammatory cell infiltration and Kupffer cell activation. Furthermore, our study revealed an inhibitory effect of cbFeD on hepatic stellate cells (HSCs) activation both in vitro and in vivo. In conclusion, cbFeD could exert a protective role against liver fibrosis in mice model induced by CCl4 that is comparable to the positive control silymarin and might be developed into a promising anti-fibrotic drug.
El texto completo de este artículo está disponible en PDF.Abbreviations : NASH, ECM, HSC, α-SMA, PPAR-γ, ASH, cbFeD, TCM, CCl4, HPF, HRP, TUNEL, ALT, AST, SEM, TIC, RT, ROS
Keywords : Codonopis bulleynana Forest ex Diels, Liver injury, Fibrogenesis, Inflammation, Hepatic stellate cell
Esquema
Vol 133
Artículo 110960- janvier 2021 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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