Adjuvant-induced arthritis is a relevant model to mimic coronary and myocardial impairments in rheumatoid arthritis - 11/02/21
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Highlights |
• | The AIA model mimics multiple aspects of cardiac abnormalities observed in RA. |
• | ET-1 and Ang-II level correlated with coronary dysfunction and cardiac hypertrophy. |
• | Arthritis is associated with an exaggerated susceptibility to ischemic injury. |
• | AIA is a relevant model to unravel the mechanisms involved in cardiac impairments. |
Abstract |
Objectives |
To determine if the adjuvant-induced arthritis model reproduced coronary and cardiac impairments observed in rheumatoid arthritis patients. The link between disease activity and circulating levels of angiotensin II and endothelin-1 have been studied, as well as the myocardial susceptibility to ischemia.
Methods |
At the acute inflammatory phase, coronary reactivity was assessed in isolated arteries, and cardiac function was studied in isolated perfused hearts, before and after global ischemia/reperfusion. Ischemic insult was evaluated by the infarct size, lactate dehydrogenase and creatine phosphokinase levels in coronary effluents. Cardiac myeloperoxidase activity was measured, as well as angiotensin II and endothelin-1 levels.
Results |
Compared to controls, adjuvant-induced arthritis had reduced coronary Acetylcholine-induced relaxation associated with cardiac hypertrophy, both being correlated with plasma levels of endothelin-1 and angiotensin II, and arthritis score. Although cardiac function at baseline was similar from controls, adjuvant-induced arthritis rats exhibited lower cardiac functional recovery, increased myeloperoxidase activity, higher infarct size and creatine phosphokinase levels after ischemia/reperfusion.
Conclusions |
The adjuvant-induced arthritis model displays coronary endothelial dysfunction associated with myocardial hypertrophy and a reduced tolerance to ischemia. This model might be useful for deciphering the pathophysiology of cardiac dysfunction in rheumatoid arthritis and paves the way for studying the role of endothelin-1 and angiotensin II.
El texto completo de este artículo está disponible en PDF.Keywords : Adjuvant-induced arthritis, Coronary dysfunction, Heart dysfunction, Ischemia/reperfusion
Esquema
Vol 88 - N° 1
Artículo 105069- janvier 2021 Regresar al número
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