Prostate-Specific Membrane Antigen PET for Assessment of Primary and Recurrent Prostate Cancer with Histopathology as Reference Standard : A Systematic Review and Meta-Analysis - 27/02/21

Doi : 10.1016/j.cpet.2020.12.001

Eivor Hernes, MD, PhD ^a,^⁎ , Mona-Elisabeth Revheim, MD, PhD, MHA ^a,^b, Knut Håkon Hole, MD, PhD ^a,^b, Andreas Julius Tulipan, MD ^a,^b, Hilde Strømme, MSc ^c, Wolfgang Lilleby, MD, PhD ^d, Therese Seierstad, MSc, PhD, MHA ^a
^a Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway
^b Institute of Clinical Medicine, University of Oslo, P.O. Box 1171 Blindern, 0318 Oslo, Norway
^c Library of Medicine and Science, University of Oslo, Sognsvannsveien 20, 0372 Oslo, Norway
^d Department of Oncology, Oslo University Hospital, P.O. Box 4953 Nydalen, 0424 Oslo, Norway

^∗Corresponding author. Department of Nuclear Medicine, Division of Radiology and Nuclear Medicine, Oslo University Hospital, P.O. Box 4956 Nydalen, 0424 Oslo, Norway.Department of Nuclear MedicineDivision of Radiology and Nuclear MedicineOslo University HospitalP.O. Box 4956NydalenOslo0424Norway

Resumen

Prostate-specific membrane antigen PET is a promising diagnostic tool in prostate cancer. The gold standard for the detection of prostate tumor and lymph node metastases is histopathology. The aim of the present review was to investigate accuracy measures of ⁶⁸Ga/¹⁸F-labeled prostate-specific membrane antigen PET tracers in primary and recurrent prostate cancer with systematic sector-based histopathology as the reference standard. A systematic literature search was performed and 34 studies were included. Overall, prostate-specific membrane antigen PET showed high specificity, but variable sensitivity to localize known prostate cancer and detect pelvic lymph node metastases.

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Keywords : Prostate cancer, PSMA PET, Histopathology, Primary tumor location, Lymph node metastases, Personalized medicine

Esquema

Screening and Study Selection

Quality Assessment

Data Extraction

Data Synthesis and Analysis

Evidence synthesis

Literature Search and Study Selection

Study and Patient Characteristics

Quality Assessment

Prostate Tumor Location

Primary Lymph Node Metastases

Recurrent Lymph Nodes Metastases

Meta-Analysis

Discussion

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Vol 16 - N° 2

P. 147-165 - avril 2021 Regresar al número

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PET-based Novel Imaging Techniques with Recently Introduced Radiotracers
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¹⁸F-Fluciclovine PET for Assessment of Prostate Cancer with Histopathology as Reference Standard : A Systematic Review
Therese Seierstad, Knut Håkon Hole, Andreas Julius Tulipan, Hilde Strømme, Wolfgang Lilleby, Mona-Elisabeth Revheim, Eivor Hernes

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Prostate-Specific Membrane Antigen PET for Assessment of Primary and Recurrent Prostate Cancer with Histopathology as Reference Standard : A Systematic Review and Meta-Analysis - 27/02/21

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