Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial - 22/03/21
Doi : 10.1016/j.jpeds.2020.12.001
Manon Tauzin, MD 1, ⁎ 
, Laetitia Marchand-Martin, MSc 2, Cécile Lebeaux, MD 3, Sophie Breinig, MD 4, Olivier Claris, MD, PhD 5, Pierre Tourneux, MD, PhD 6, Cénéric Alexandre, MD 7, Corinne Levy, MD, PhD 8, 9, 10, Camille Jung, MD, PhD 10, Agnès Dechartres, MD, PhD 11, Xavier Durrmeyer, MD, PhD 1, 2, 12
for the
, Laetitia Marchand-Martin, MSc 2, Cécile Lebeaux, MD 3, Sophie Breinig, MD 4, Olivier Claris, MD, PhD 5, Pierre Tourneux, MD, PhD 6, Cénéric Alexandre, MD 7, Corinne Levy, MD, PhD 8, 9, 10, Camille Jung, MD, PhD 10, Agnès Dechartres, MD, PhD 11, Xavier Durrmeyer, MD, PhD 1, 2, 12for the
PREmedication Trial for Tracheal Intubation of the NEOnate Research Group∗
Barcat Lucile, MD, Boddaert Sophie, PharmD, Caron-Lesenechal Evelyne, MD, Carpentier Eléonore, MD, Chazal Christèle, MD, Delaunay Mickaël, CRA, Degorre Coralie, MD, Fontaine Cécile, MD, Ghyselen Laurent, MD, Goudjil Sabrina, MD, Kongolo Guy, MD, Leke André, MD, Moreau François, MD, Moussa Yasser, MD, Popov Isabelle, CRA, Ramadan GhostineGhida, MD, Razafimanantsoa Lucie, MD, Romeo Bernard, MD, Tellai Leila, MD, Adamon Latif, MD, Alexandre Mélanie, MD, Alix Antoine, PharmD, Bellot Anne, MD, Crosse Julien, MD, Dorriere Valérie, MD, Guillemin Marie-Gabrielle, MD, Guillois Bernard, MD, PhD, Leport Mathilde, MD, Panici Maud, MD, Pinto Da Costa Nathalina, MD, Rots Delphine, CRA, Savey Baptiste, MD, Trentesaux Anne-Sophie, MD, Azcona Barbara, MD, Bacher Marjorie, MD, Boiron Emilie, MD, Bourgoin Laura, MD, Bouafif Firas, MD, Brussieux Maxime, CRA, Caeymaex Laurence, MD, PhD, Dahan Sonia, MD, Danan Claude, MD, Dassieu Gilles, MD, Dassy Audrey, PharmD, Decobert Fabrice, MD, Henri Hélène, MD, Jourdan Diane, MD, Layouni Inès, MD, Le Gouez Morgane, MD, Merlot Elodie, MD, Millot Estelle, MD, Peluchon Anne, RN, Ratsimbazafy Lanto, MD, Renault Anais, MD, Toure Judith, CRA, Vedrenne-Cloquet Meryl, MD, Younes Bouthaina, PharmD, An Chu Huu Kim, MD, Beissel Anne, MD, Bellemin Karine, MD, Blanc Sébastien, MD, Bouamari Hocine, MD, Breant Valentine, MD, Bruschet Lydie, RN, Clamadieu Catherine, MD, Cornaton Elise, CRA, Cottin Xavier, MD, Cudel Muriel, PharmD, Gauthier-Moulinier Hélène, MD, Plaisant Franck, MD, Prudon Malika, MD, Arberet Camille, MD, Beuchee Alain, MD, PhD, Chauvel Jennifer, MD, Delahaye Séverine, MD, Deniau Anne-Laure, PharmD, Gaillot Théophile, MD, Lallemant Carine, MD, Lamour Anne-Marie, CRA, Lebas Fanny, MD, Noseda Céline, MD, Ozanne Bruno, MD, Pladys Patrick, MD, PhD, Sauret Anne, MD, Thomas de La Pintiere Armelle, MD, Tirel Olivier, MD, Bouissou Antoine, MD, Cantagrel Sylvain, MD, Chantreuil Julie, MD, Decock-Giraudaud Aliette, CRA, Labarthe François, MD, Meteier Véronique, PharmD, Norbert Karine, MD, Perez Thierry, MD, Planchenault Déborah, MD, Roullet Nicolas, MD, Saliba Elie, MD, PhD, Suc Anne-Laure, MD, eToulouse: Alberge Corinne, MD, Amadieu Romain, MD, Auriol Françoise, Senior CRA, Berthomieu Lionel, MD, Bloom Marie-Claude, MD, Eyvrard Frédéric, PharmD, Gineste Martine, MD, Jurado Camille, PharmD, Kieffer Isabelle, CRA, Lelong Sandrine, CRA, Marcoux Marie-Odile, MD, Mus Marianne, CRA, Pelluau Sonia, MD, Gaba Mabel, CRA, Issa Amelle, CRA, Lacour Sandrine, CRA, Bechet Stéphane, MSc, Boucherat Michel, MD, Cohen Robert, MD, PhD, Prieur Claire, CRA, Ramay Isabelle, CRA
1 Neonatal Intensive Care Unit, CHI Créteil, Créteil, France
2 Université de Paris, CRESS, INSERM, INRA, Paris, France
3 Réseau Périnatal du Val de Marne, CHI Créteil, Créteil, France
4 Pediatric and Neonatal Intensive Care Unit, CHU Toulouse, Toulouse, France
5 Neonatal Intensive Care Unit, Hospices Civils de Lyon, Lyon, France
6 Neonatal Intensive Care Unit, CHU Amiens, Amiens, France
7 Neonatal Intensive Care Unit, CHU Caen, Caen, France
8 ACTIV, Créteil, France
9 IMRB- GRC GEMINI, Université Paris Est, Créteil, France
10 Clinical Research Center, CHI Créteil, Créteil, France
11 Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP. Sorbonne Université, Hôpital Pitié Salpêtrière, Département de Santé Publique, Paris, France
12 Université Paris Est Créteil, Faculté de Médecine de Créteil, IMRB, GRC CARMAS, Créteil, France
∗Reprint requests: Manon Tauzin, MD, Réanimation néonatale, CHI Créteil, 40 avenue de Verdun, 94000 Créteil, FranceRéanimation néonataleCHI Créteil40 avenue de VerdunCréteil94000France
Abstract |
This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire.
Trial registration Clinicaltrials.gov: NCT01490580.
El texto completo de este artículo está disponible en PDF.Keywords : anesthesia, pain, newborn, neurodevelopment, ages and stages questionnaire, neurotoxicity
Abbreviations : ASQ, PRETTINEO
Esquema
© 2020
Elsevier Inc. Reservados todos los derechos.
Vol 231
P. 273 - avril 2021 Regresar al número
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