Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer - 17/06/21
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Abstract |
Piezo-type mechanosensitive ion channel component 1 (Piezo1) is a mechanosensitive ion channel protein that is evolutionarily conserved and multifunctional. It plays an important role as an oncogenic mediator in several malignant tumors. It mediates the proliferation, migration, and invasion of a variety of cancer cells through various mechanisms. Multiple studies have shown that the expression of Piezo1 is related to the clinical characteristics of senescence and cancer patients, making Piezo1 useful as a new biomarker for the diagnosis and prognosis of a variety of human cancers. Manipulating the expression or function of Piezo1 is a potential therapeutic strategy for different diseases. Piezo1 may be a promising tumor biomarker and therapeutic target. Here we review the biological function, mechanism of action, and potential clinical significance of Piezo1 in oncogenesis and progression.
El texto completo de este artículo está disponible en PDF.Highlights |
• | This paper reviews the recent literature on piezo1. |
• | According to the classification of disease and mechanism, the role of piezo1 on cancer field was summarized. |
• | It is concluded that piezo1 is a biomarker of human cancer and may become a potential target for cancer diagnosis and treatment. |
• | This review is valuable to all who are engaged in this field. |
Abbreviations : Piezo1, MA, 5-FU, TFF1, YAP, FAK, GC, OSCC, CRC, PCa, BC, OS, LC, NSCLC, ECM, TCGA, GENT2
Keywords : Piezo-type mechanosensitive ion channel component 1 (Piezo1), Cancer, Biomarker, Therapeutic target, Mechanism of action
Esquema
Vol 140
Artículo 111692- août 2021 Regresar al número
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