An Institutional experience with primary hyperparathyroidism in the elderly over two decades - 12/08/21
, Tina W.F. Yen, MD, MS, Kara Doffek, BS, Sophie Dream, MD, Ioanna Mazotas, MD, Douglas B. Evans, MD, Tracy S. Wang, MD, MPHAbstract |
Background |
Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (pHPT) and is associated with low morbidity. This study examined the severity of disease and outcomes of parathyroidectomy based on patient age at a high-volume institution.
Methods |
This is a retrospective review of sporadic pHPT patients who underwent initial parathyroidectomy. To study disease severity over time, patients were divided into timeframes: 1999–2007, 2007–2012, and 2013–2018. Elderly was defined as age ≥75 years.
Results |
Over time, the elderly had progressively lower preoperative calcium (11.0, 10.7, 10.7; p = 0.05) and PTH (150.4, 111.9, 107.9; p < 0.001) levels. By age, there was no difference in preoperative calcium (10.8, 10.9; p = 0.91) or in rates of recurrent laryngeal nerve injury, hypoparathyroidism, or persistent/recurrent pHPT.
Conclusions |
Over the 3 time periods of the study, elderly patients had progressively lower calcium and PTH levels. There was no difference in endocrine-specific complications between the age groups, suggesting that parathyroidectomy in the elderly is safe and therefore, age-associated morbidity should not preclude parathyroidectomy.
El texto completo de este artículo está disponible en PDF.Highlights |
• | Parathyroidectomy for primary hyperparathyroidism is safe with elderly patients. |
• | Older patients have no associated increase in morbidity. |
• | There is no difference in endocrine specific complications between age groups. |
• | Age does not affect the incidence of persistent or recurrent hyperparathyroidism. |
Keywords : Primary hyperparathyroidism, Elderly, Parathyroidectomy, Outcomes
Esquema
Vol 222 - N° 3
P. 549-553 - septembre 2021 Regresar al número
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