Side effects of messenger RNA vaccines and prior history of COVID-19, a cross-sectional study - 23/12/21
, Ravali Janagama, MD, MS b, #, Siva H. Yedlapati, MD, MPH c, Neelakanta Kanike, MD d, Viswanath Gajula, MD e, Rajasekhar R. Madathala, MD f, Swati Poddar, MD g, Neelakanta Sukka, MD h, Hanumantha R. Jogu, MD i, Shailaja Racherla, MBBS j, Isha Shah, MD k
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Highlights |
• | Prior history of COVID-19, a predictor for severity of side effects. |
• | Prior history COVID-19 associated with transient time off from work post-vaccination. |
• | Paid time off provision may help with higher compliance and acceptance. |
Resumen |
Background |
There are concerns regarding immunogenicity with coronavirus disease 2019 (COVID-19) mRNA vaccines among persons with prior history of COVID-19 (PHC). This study was to analyze the short-term side effects of mRNA vaccines among health care workers (HCWs) with and without PHC.
Methods |
A cross-sectional study was performed using an independent online survey questionnaire that gathered responses from HCWs.
Results |
Among 1,475 HCWs, 1268 (85.97%) completed the survey, 102/1268 (44/447 in Moderna group and 58/821 in Pfizer-BioNTech group) reported PHC during pre-vaccination period. Symptoms of flushing/P = .05, brain fogging/P= .005, vertigo/P= .041, numbness/P= .023, diarrhea/P= .047, hives/P= .028, itching/P= .028, swelling of lips/mouth/P= .001, shortness of breath/P= .022, and anxiety/P= .048 have greater occurrence among Pfizer-BioNtech group with PHC when compared to Pfizer-BioNtech group with no PHC. Symptoms of chills/P= .027, flushing/P= .045, tremor/P= .05, muscle spasm/P= .039, vomiting/P= .031, diarrhea/P= .015, and cough/P= .011 have higher occurrence among Moderna group with PHC when compared to Moderna group with no PHC.
Conclusions |
Few short-term side effects among mRNA vaccine recipients with PHC may have necessitated transient time-off from work. The PHC can be considered as a predictor for severity of side effects. While the vaccination program continues in the United States, a future COVID legislation that mandates vaccination among employees along with paid time off provision may help with higher compliance and acceptance.
El texto completo de este artículo está disponible en PDF.Key Words : Prior infection, SARS-CoV-2, Moderna, Pfizer-BioNtech, legislation, Predictors
Esquema
| Conflicts of interest: None to report. |
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| Author contributions: All authors contributed significantly to this work. Conceptualization and proposal writing was done by R.A.K.K. and R.J.; methodology and data collection by R.J. and R.A.K.K.; software and statistical analysis, R.A.K.K. and S.R.; writing—original draft preparation, R.A.K.K., R.J., S.H.Y.; writing—review and editing, S.H.Y., N.K., S.P., R.R.M., V.G., H.R.J. and I.S.; supervision by R.J. and R.A.K.K.; project administration by R.J. and R.A.K.K. All authors have read and agreed to the published version of the manuscript. |
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| Ethics approval and consent to participate: The approval for the parent study was obtained from the Institutional Review Board at Cape Fear Valley Health System, 1638 Owen Drive, Fayetteville, NC 28304. Informed consent was obtained from all survey participants involved in the study. |
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| Availability of data and materials: Data is available upon request. |
Vol 50 - N° 1
P. 8-14 - janvier 2022 Regresar al número
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