Radiologists have an integral role in the diagnosis of bone and soft-tissue tumors beyond image interpretation. Image-guided biopsies are used to diagnose and stage musculoskeletal tumors. This article reviews the steps of minimally invasive image-guided biopsies, from prebiopsy planning through postbiopsy pathology follow-up. Helpful techniques to perform and troubleshoot these procedures adequately and safely are detailed. Radiologists are also expanding the treatment options available for many benign and malignant bone and soft-tissue tumors. Some of these more frequently performed procedures include percutaneous thermal ablation and cementoplasty. The evidence, indications, and basic principles of these interventional procedures are also discussed.