Urinary exosomes: Emerging therapy delivery tools and biomarkers for urinary system diseases - 27/05/22
Abstract |
Urinary exosomes (UE) are small circular membranous vesicles with a lipid bilayer with a diameter of 40–160 nm secreted by epithelial cells of the kidney and genitourinary system, which can reflect the physiological and functional status of secretory cells. Protein and RNA in exosomes can be used as markers for diseases diagnosis. Urine specimens are available and non-invasive. The protein and RNA in UE are more stable than the soluble protein and RNA in urine, which have broad application prospects in the diagnosis of urinary system diseases. This article reviews the recent advances in the application of protein or RNA in UE as markers to the diagnosis of urinary system diseases.
El texto completo de este artículo está disponible en PDF.Highlights |
• | The protein and RNA in UE are more stable than the soluble protein and RNA in urine. |
• | UEs have broad application prospects in the diagnosis of kidney diseases. |
• | UEs have broad application prospects for tumor diagnosis in the urinary system. |
Abbreviations : MVB, RNAs, uEVs, AKI, CKD, ATF3, WT1, AQP1, I/R, IRI, NGAL, CD2AP, GFR, DN, CP, T1DN, AUC, T2DN, T2DM, TSP1, IgAN, TBMN, FSGS, MCD, LN, SLE, LNIV-CC, PKD, PC1, PC2, TMEM2, GS, BS, SLTs, NCC, NKCC2, PCa, PCA3, ERG, LncRNA, ITGA3, ITGB1, BCa, EDIL-3, GALNT, LASS2, ccRCC, esRNAs, MMP-9, DKK4, CAIX
Keywords : Urinary exosomes, Biomarker, Protein, RNA, Urinary system diseases
Esquema
Vol 150
Artículo 113055- juin 2022 Regresar al número
Artículo precedente
- Adamalysins in COVID-19 – Potential mechanisms behind exacerbating the disease
- Ivo Ricardo de Seabra Rodrigues Dias, Zhijian Cao, Hang Fai Kwok
- Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
- Sheema Hashem, Tayyiba Akbar Ali, Sabah Akhtar, Sabah Nisar, Geetanjali Sageena, Shahid Ali, Sharefa Al-Mannai, Lubna Therachiyil, Rashid Mir, Imadeldin Elfaki, Mohammad Muzaffar Mir, Farrukh Jamal, Tariq Masoodi, Shahab Uddin, Mayank Singh, Mohammad Haris, Muzafar Macha, Ajaz A. Bhat
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
¿Ya suscrito a @@106933@@ revista ?