Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease - 31/08/22
Abstract |
Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria transfer can promote wound healing and can potentially be applied to the repair of damaged tissue, but the specific mechanisms and regulatory factors involved remain unclear. In this review, we discuss the mechanistic basis of mitochondria transfer and factors that restore mitochondrial function in injured somatic cells.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | Mesenchymal stem cell (MSC) mitochondria transfer is a potential strategy in cell therapy. |
• | Tunnel nanotubes, microvesicles, gap junctions and cell fusion are the most common patterns of MSC mitochondrial transfer. |
• | MSC mitochondria transfer is widely used in the treatment of cardiovascular injury，lung injury，brain injury，skin injury，renal injury, eye injury, etc. |
Abbreviations : MSCs, TNTs, MVs, EVs, GJs, GJCs, GJIC, Cx, Miro1, AAI, LPS, BM-MSCs, NF-κB, HUVECs, hBMSCs, TNF-α, ROS, hMSCs, H/R, NMCMs, PMVECs, ARDS, AM
Keywords : Mitochondrial transfer, Mesenchymal stem cells, Tissue damage
Esquema
Vol 153
Artículo 113482- septembre 2022 Regresar al número
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