Anakinra for refractory pustular psoriasis: A phase II, open-label, dose-escalation trial - 30/11/22
Doi : 10.1016/j.jaad.2022.07.065
Haley B. Naik, MD, MHSc a, ⁎ 
, Dominique C. Pichard, MD b, Daniella M. Schwartz, MD c, Michelle O'Brien, RN, BSN b, Matthew Masciocchi, BSc d, Julie Thompson, BSN b, H. Nida Sen, MD e, Seth M. Steinberg, PhD f, Sandra A. Mitchell, PhD, CRNP g, Adriana A. de Jesus, MD, PhD h, Timothy H. McCalmont, MD a, i, Amit Dey, MD j, Rachel K. Rosenstein, MD, PhD b, Zuoming Deng, PhD k, Raphaela Goldbach-Mansky, MD, MHS h, Nehal N. Mehta, MD j, Edward W. Cowen, MD, MHSc b
, Dominique C. Pichard, MD b, Daniella M. Schwartz, MD c, Michelle O'Brien, RN, BSN b, Matthew Masciocchi, BSc d, Julie Thompson, BSN b, H. Nida Sen, MD e, Seth M. Steinberg, PhD f, Sandra A. Mitchell, PhD, CRNP g, Adriana A. de Jesus, MD, PhD h, Timothy H. McCalmont, MD a, i, Amit Dey, MD j, Rachel K. Rosenstein, MD, PhD b, Zuoming Deng, PhD k, Raphaela Goldbach-Mansky, MD, MHS h, Nehal N. Mehta, MD j, Edward W. Cowen, MD, MHSc b a Department of Dermatology, University of California, San Francisco, California
b Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland
c Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
d Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland
e Clinical and Translational Immunology Unit, Laboratory of Immunology, National Eye Institute, Bethesda, Maryland
f Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland
g Division of Cancer Control and Population Sciences, Outcomes Research Branch, National Cancer Institute, Rockville, Maryland
h Translational Autoinflammatory Diseases Section (TADS), LCIM, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
i Department of Pathology, University of California, San Francisco, California
j Section of Inflammation and Cardiovascular Diseases, National Institute of Heart, Lung and Blood Diseases, Bethesda, Maryland
k Biodata Mining and Discovery Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland
∗Correspondence to: Haley B. Naik, MD, MHSc, Department of Dermatology, University of California, San Francisco, 2340 Sutter St, MC 0808, San Francisco, CA 94143-0808Department of DermatologyUniversity of California, San Francisco2340 Sutter St, MC 0808San FranciscoCA94143-0808
| Funding sources: This work was supported by the intramural programs of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, United States, National Cancer Institute, United States, National Heart, Lung and Blood Institute, United States and National Institute of Allergy and Infectious Disease, United States. Study drug was provided through a Clinical Trials Agreement between the National Cancer Institute and SOBI. Haley Naik is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS K23 AR074531). |
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| IRB approval status: Reviewed and approved by the National Cancer Institute and National Institutes of Health Institutional Review Boards; IRB # 13-C-0071/13-AR-0071. |
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| Key words: acrodermatitis of Hallopeau; anakinra; autoinflammation; inflammatory arthritis; pustular psoriasis; Sneddon-Wilkinson disease. |
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| Reprints not available from the authors. |
© 2022
American Academy of Dermatology, Inc. Reservados todos los derechos.
Vol 87 - N° 6
P. 1380-1383 - décembre 2022 Regresar al número
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