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Ethnicity Is Associated With Differing Presentation and Outcomes of Patients Undergoing Aortic Valve Replacement for Calcific Aortic Stenosis in Aotearoa New Zealand - 16/12/23

Doi : 10.1016/j.hlc.2023.08.016 
Ramanen Sugunesegran, MBChB a, Sally Harrison, MBBS a, Dominic Parry, FRACS a, b, Katherine Sneddon, PhD c, Michel de Lange, PhD d, e, Sean Galvin, FRACS b, f, Ralph Stewart, MBChB g, Bernard Wong, MBChB h, Gillian Whalley, PhD c, Philip Davis, FRACS a, b, Sean Coffey, MBBS c, i,
a Department of Cardiothoracic Surgery, Dunedin Hospital, Dunedin, New Zealand 
b New Zealand National Cardiac Surgical Clinical Network, Wellington, New Zealand 
c Department of Medicine, HeartOtago, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand 
d Department of Biostatistics, University of Otago, Dunedin, New Zealand 
e Pacific Edge Ltd., Dunedin, New Zealand 
f Department of Cardiothoracic Surgery, Wellington Hospital, Wellington, New Zealand 
g Department of Cardiology, Auckland City Hospital, Auckland, New Zealand 
h Department of Cardiology, North Shore Hospital, Auckland, New Zealand 
i Department of Cardiology, Dunedin Hospital, Dunedin, New Zealand 

Corresponding author at: Department of Medicine, University of Otago, PO Box 56, Dunedin, New Zealand 9054Department of MedicineUniversity of OtagoPO Box 56Dunedin9054New Zealand

Abstract

Aim

Surgical aortic valve replacement (SAVR) has been the gold standard for treatment of severe symptomatic aortic stenosis (AS) for decades. We examined whether ethnic differences exist in the presentation and outcomes of patients undergoing aortic valve replacement (AVR) for AS in New Zealand.

Methods

Patients of New Zealand European, Māori, and Pacific Island ethnicities undergoing SAVR with or without other procedures in New Zealand public hospitals from 2017 to 2019 were included. Major postoperative outcomes were compared between ethnic groups, with 30-day mortality being the primary outcome.

Results

A total of 1,175 patients were included: 1,085 European, 50 Māori, and 40 Pacific. The mean age was 71.1±9.4 years, and men accounted for more than half of all patients (69.9%). Māori (64.7±9.4 years) and Pacific (65.4±10.1 years) patients were younger when undergoing SAVR compared with European patients (71.7±9.2; analysis of variance p<0.001). Māori and Pacific patients had a higher prevalence of diabetes, poorer renal function, and worse left ventricular function; 30-day mortality was higher in Māori and Pacific compared with European patients (6% and 10% vs 2.4%, respectively; Fisher’s exact test p=0.011), with odds ratio of 3.06 (95% confidence interval [CI] 0.88–10.66) for Māori patients after adjustment for EuroSCORE II and odds ratio of 5.23 (95% CI 1.79–16.07) for Pacific patients.

Conclusions

There are significant differences in presentation and outcomes of patients undergoing AVR in New Zealand. Māori and Pacific patients undergo SAVR at a younger age, have more preoperative comorbidities, and have higher rates of 30-day mortality than European patients.

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Keywords : Aortic valve replacement, Aortic stenosis, New Zealand, Surgery, Ethnicity


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© 2023  The Author(s). Publicado por Elsevier Masson SAS. Todos los derechos reservados.
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Vol 32 - N° 12

P. 1512-1519 - décembre 2023 Regresar al número
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