Copper nitroprusside: An innovative approach for targeted cancer therapy via ROS modulation - 04/02/24
, Md. Mahbubur Rahman c, Michele Bartoletti d, e, Simona Kranjc Brezar f, Maja Cemazar f, Vincenzo Canzonieri a, g, Flavio Rizzolio a, b, ⁎ , Isabella Caligiuri aAbstract |
The clinical application of nanomaterials for chemodynamic therapy (CDT), which generate multiple reactive oxygen species (ROS), presents significant challenges. These challenges arise due to insufficient levels of endogenous hydrogen peroxide and catalytic ions necessary to initiate Fenton reactions. As a result, sophisticated additional delivery systems are required. In this study, a novel bimetallic copper (II) pentacyanonitrosylferrate (Cu(II)NP, Cu[Fe(CN) 5 NO]) material was developed to address these limitations. This material functions as a multiple ROS generator at tumoral sites by self-inducing hydrogen peroxide and producing peroxynitrite (ONOO-) species. The research findings demonstrate that this material exhibits low toxicity towards normal liver organoids, yet shows potent antitumoral effects on High Grade Serous Ovarian Cancer (HGSOC) organoid patients, regardless of platinum resistance. Significantly, this research introduces a promising therapeutic opportunity by proposing a single system capable of replacing the need for H2O2, additional catalysts, and NO-based delivery systems. This innovative system exhibits remarkable multiple therapeutic mechanisms, paving the way for potential advancements in clinical treatments.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Schematic illustration showing Cu(II)NP as H2O2 self-supplying agent for multiple ROS-generation.
Schematic illustration showing Cu(II)NP as H2O2 self-supplying agent for multiple ROS-generation.ga1El texto completo de este artículo está disponible en PDF.
Highlights |
• | CuNP overcome the low endogenous H2O2 level issue, due to which CDT is severely restricted by increasing the H2O2 level. |
• | CuNP provides (Fe+2, Cu+2) dual metal cations in a single system to improve the catalytic activity of Fenton reaction. |
• | CuNP also produced ONOO− as apoptosis inducer specifically at tumoral sites. |
• | This single system also inhibits the expression of multiple cancerous genes e.g., CuNP inhibits (SOD1, c-myc, NF-κB). |
Keywords : Self-therapeutic, Copper nitroprusside, Peroxynitrite, Self-supplying hydrogen peroxide
Esquema
Vol 171
Artículo 116017- février 2024 Regresar al número
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