Myocarditis and pericarditis risk with mRNA COVID-19 vaccination compared to unvaccinated individuals: A retrospective cohort study in a Spanish Tertiary Hospital - 04/02/24
, Francisco Javier Guijarro Eguinoa a, Arturo Gómez López de las Huertas a, María Jiménez-González b, c, Elena Ramírez a, ⁎, 2
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Abstract |
Objective |
This study compared the incidence of pericarditis and myocarditis in patients exposed to mRNA COVID-19 vaccines to the incidence in those who were not vaccinated, considering the incidence of these conditions resulting from COVID-19 infection.
Methods |
This was a retrospective cohort study of individuals assigned to health area of La Paz University Hospital in Spain. The exposure factor was vaccination with mRNA COVID-19 vaccines between December 27th, 2020 and January 9th, 2022 with a minimum follow-up of one month. The outcome was the incidence of pericarditis or myocarditis in these individuals.
Results |
The incidence of pericarditis and myocarditis in the total population exposed to at least one dose of mRNA COVID-19 vaccines was 5/100,000 (CI95%:3 to 8 per 100,000), compared to 70/100,000 (CI95%: 66 to 92 per 100,000) in those who were not vaccinated. In the adolescent population (aged 12–17), the incidence was 10/100,000 in vaccinated population (CI95%: 5 to 45 per 100,000) compared to 20/100,000 in unvaccinated (CI95%: 6 to 79 per 100,000). The incidence of pericarditis or myocarditis in patients with COVID-19 infection was 200/100,000 people (CI95%: 114 to 306 per 100,000). The most common cause of pericarditis and myocarditis in the cohort was idiopathic/infectious (74 cases). Cases of myocarditis attributed to COVID-19 infection were more severe and had higher mortality rates compared to cases with other causes.
Conclusion |
The incidence of pericarditis and myocarditis in patients exposed to mRNA COVID-19 vaccines was lower than in those who were not vaccinated, especially in adults.The most common cause of pericarditis and myocarditis was idiopathic/infectious, but the most frequent cause in adolescent patients was mRNA COVID-19 vaccination. Cases of myocarditis due to COVID-19 infection were more severe and had greater mortality.
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Highlights |
• | The incidence of pericarditis/myocarditis in total and adult population exposed to mRNA COVID-19 vaccine was 5 per 100,000. |
• | Most cases of pericarditis and myocarditis exposed to mRNA COVID-19 vaccines were young men who received 2 doses. |
• | The incidence of pericarditis/myocarditis due to COVID-19 infection was 20 times higher than those due to mRNA vaccines. |
• | The most frequent cause of pericarditis/myocarditis in adolescent patients was mRNA COVID-19 vaccination. |
Keywords : COVID-19 vaccines, Adverse drug reactions, Causality algorithms, Myocarditis, Pericarditis
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Vol 171
Artículo 116181- février 2024 Regresar al número
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