Molecular Allergology and Component-Resolved Diagnosis in Current Clinical Practice - 22/02/24

Doi : 10.1016/j.otc.2023.10.003

Michael S. Benninger, MD ^a,^⁎ , Gary A. Falcetano, PA-C ^b
^a Department of Otolaryngology-Head and Neck Surgery, Cleveland Clinic Lerner College of Medicine, Head and Neck Institute, The Cleveland Clinic, 9500, Euclid Avenue. A-71, Cleveland, OH 44195, USA
^b Immuno Diagnostics Division, Thermo Fisher Scientific, 4169 Commercial Avenue, Portage, MI 49002, USA

^∗Corresponding author.

Resumen

Specific immunoglobulin E immunodiagnostics is becoming a convenient way to identify allergic patients and their specific allergies. These results are comparable to skin testing and may be more accessible for some populations. Each allergen contains thousands of molecules but only a few of these molecules are allergenic to humans. Each allergen has a number of individual components—generally proteins—which have different characteristics that may impact the effects of sensitization. Identification of the specific component allows for differentiation of the true allergies and can help to determine the risk of a significant clinical response.

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Keywords : Allergy, Molecular allergology, Component-resolved diagnostics