Theabrownin from Qingzhuan tea prevents high-fat diet-induced MASLD via regulating intestinal microbiota - 27/04/24
Abstract |
The aim of this study was to investigate whether the therapeutic effect of theabrownin extracted from Qingzhuan tea (QTB) on metabolic dysfunction-associated steatosis liver disease (MASLD) is related to the regulation of intestinal microbiota and its metabolite short-chain fatty acids (SCFAs). Mice were divided into four groups and received normal diet (ND), high-fat diet (HFD) and HFD+QTB (180, 360 mg/kg) for 8 weeks. The results showed that QTB significantly reduced the body weight of HFD mice, ameliorated liver lipid and dyslipidemia, and increased the level of intestinal SCFAs in HFD mice. The results of 16 S rRNA showed that the relative abundance of Bacteroides, Blautia and Lachnoclostridium and their main metabolites acetate and propionate were significantly increased after QTB intervention. The relative abundance of Colidextribacter, Faecalibaculum and Lactobacillus was significantly reduced. QTB can also significantly up-regulate the expression of ATGL, PPARα, FFAR2 and FFAR3, and inhibit the expression of LXRα, SREBP-1c, FAS and HMGCR genes. This makes it possible to act as a prebiotic to prevent MASLD.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | The therapeutic effect of theabrownin on MASLD was demonstrated. |
• | Regulating intestinal microbiota and its metabolites in mice. |
• | The SCFAs receptors may be potential therapeutic targets for MASLD. |
Keywords : Theabrownin, MASLD, Obesity, Intestinal microbiota, Short-chain fatty acids
Esquema
Vol 174
Artículo 116582- mai 2024 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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