Peripheral artery disease risk factors: A focus on lipoprotein(a) - 17/10/24
, Elisabetta Grolla b, Giuliana Autiero a, Fabio Presotto a
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Highlights |
• | Well-established and strong link between high Lp(a) concentration and CHD. |
• | Evidence regarding PAD and CA is not as conclusive. |
• | This review summarizes the relationships between Lp(a), PAD and CA. |
Abstract |
There is a well-established and strong link between high lipoprotein(a) concentration and coronary heart disease, but the evidence regarding peripheral artery disease and carotid atherosclerosis is not as conclusive. This review aims to summarize the relationships between lipoprotein(a), peripheral artery disease and carotid atherosclerosis, in order to try to understand the weight of lipoprotein(a) in determining the development, progression and any complications of atherosclerotic plaque at the carotid and peripheral artery level. There is currently no effective therapy to reduce lipoprotein(a) concentration, but understanding its significance as a vascular risk factor is the starting point to then explore (when effective therapies become available) if there is the possibility, even in patients with peripheral artery disease and carotid atherosclerosis, to achieve better control of the residual vascular risk that is ultimately induced by lipoprotein(a).
El texto completo de este artículo está disponible en PDF.Keywords : Peripheral artery disease, Lipoprotein(a), Carotid artery disease
Abbreviations : apo(a), apoB, CI, CVD, HR, Lp(a), MALE, OR, OxPL, PAD, RNA
Esquema
Vol 117 - N° 10
P. 584-589 - octobre 2024 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.