Buscar
image du produit
The Journal of nutrition, health and aging

Model construction for biological age based on a cross-sectional study of a healthy Chinese han population - 06/12/24

Doi : 10.1007/s12603-017-0874-7 
W. Zhang 1, L. Jia 2, G. Cai 1, F. Shao 3, H. Lin 4, Z. Liu 5, F. Liu 6, D. Zhao 1, Z. Li 1, X. Bai 7, Z. Feng 1, XueFeng Sun 1, 8, * , Xiang-Mei Chen 1, 8, *
1 Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, 100853, Beijing, China 
2 Department of Nephrology, Second Hospital of Jilin University, 218 Ziqiang Street, 130041, Changchun, Jilin Province, China 
3 Department of Nephrology, People's Hospital of Henan Province, 7 Weiwu Road, 450003, Zhengzhou, Henan Province, China 
4 Department of Nephrology, First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, 116011, Dalian, Liaoning Province, China 
5 Department of Nephrology, First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, 450003, Zhengzhou, Henan Province, China 
6 Department of Nephrology, Second Xiangya Hospital, Central South University, 139 Renmin Middle Street, 410011, Changsha, Hunan Province, China 
7 Department of Gerontology and Geriatrics, ShengJing Hospital of China Medical University, 155 Nanjing North Street, 110001, Shenyang, Liaoning Province, China 
8 Department of Nephrology, Kidney Institute of Chinese PLA, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, 100853, Beijing, China 

conectar o crear una cuenta

Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
Artículo gratuito.

Conéctese para beneficiarse!

Abstract

Objectives

Biological age (BA) has been proposed to evaluate the aging status in an objective way instead of chronological age (CA). The purpose of our study is to construct a more precise formula of BA in the cross-sectional study based on a largest-ever sample of our studies. This formula aims at better evaluation of body function and exploring the disciplines of aging in different genders and age stages.

Methods

A total of 1,373 healthy Chinese Han (age range, 19-93 years) were recruited from five cities in China, including 581 males and 792 females. Physical examination, blood routine, blood chemistry, and other lab tests were performed to obtain a total of 74 clinical variables. Then, the principal component analysis (PCA) was used to select variables and estimate BA. The BA formula was further validated in a population with some diseases (n=266), including cardiovascular diseases, type 2 diabetes, kidney diseases, pulmonary diseases, cancer and disorders in nervous system.

Results

The BA formula was constructed as follows: BA = 0.358 (pulse pressure) + 0.258 (trail making test)–11.552 (mitral valve E/A peak) + 26.383 (minimum intima-media thickness) + 31.965 (Cystatin C) + 0.163 (CA)–3.902. In validation of the formula, BAs of patients were older than those of healthy persons. The BA accelerates faster in the middle-aged population than in the elderly population (>75 years old).

Conclusion

This BA formula can reflect health condition changes of aging better than CA in a Chinese Han population.

El texto completo de este artículo está disponible en PDF.

Keywords : Biological age, chronological age, principal component analysis


Esquema


© 2017  © 2017 SERDI Publisher.. Publicado por Elsevier Masson SAS. Todos los derechos reservados.
Añadir a mi biblioteca Eliminar de mi biblioteca Imprimir
Exportación

    Exportación citas

  • Fichero

    •

  • Contenido

    •

Vol 21 - N° 10

P. 1233-1239 - décembre 2017 Regresar al número
Artículo precedente Artículo precedente
  • Dietary approach to stop hypertension with sodium reduction for Chinese Canadians (Dashna-CC): A pilot randomized controlled trial
  • Ping Zou, C.-L. Dennis, R. Lee, M. Parry
| Artículo siguiente Artículo siguiente
  • Perceived resources as a predictor of satisfaction with food-related life among Chilean elderly: An approach with generalized linear models
  • G. Lobos, B. Schnettler, K.G. Grunert, C. Adasme

Bienvenido a EM-consulte, la referencia de los profesionales de la salud.

@@150455@@ Voir plus

Mi cuenta

Aide & support

Declaración CNIL

EM-CONSULTE.COM se declara a la CNIL, la declaración N º 1286925.

En virtud de la Ley N º 78-17 del 6 de enero de 1978, relativa a las computadoras, archivos y libertades, usted tiene el derecho de oposición (art.26 de la ley), el acceso (art.34 a 38 Ley), y correcta (artículo 36 de la ley) los datos que le conciernen. Por lo tanto, usted puede pedir que se corrija, complementado, clarificado, actualizado o suprimido información sobre usted que son inexactos, incompletos, engañosos, obsoletos o cuya recogida o de conservación o uso está prohibido.
La información personal sobre los visitantes de nuestro sitio, incluyendo su identidad, son confidenciales.
El jefe del sitio en el honor se compromete a respetar la confidencialidad de los requisitos legales aplicables en Francia y no de revelar dicha información a terceros.

Todo el contenido en este sitio: Copyright © 2026 Elsevier, sus licenciantes y colaboradores. Se reservan todos los derechos, incluidos los de minería de texto y datos, entrenamiento de IA y tecnologías similares. Para todo el contenido de acceso abierto, se aplican los términos de licencia de Creative Commons.