Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens - 15/05/25

Doi : 10.1016/j.ajic.2025.02.008

Jennifer E. Peel, MPH ^a, Elizabeth Jardinella, BS ^b, Yue Qu, PhD ^c, Jessica A. Plante, PhD ^a,^d, Brooke M. Mitchell, BS ^a,^d, Jordyn L. Walker, BA ^a,^d, Roberto P. Garofalo, MD ^c, Scott C. Weaver, PhD ^a,^d, Kenneth S. Plante, PhD ^a,^d, Trevor Brasel, PhD ^a,^b, William S. Lawrence, PhD ^a,^⁎
^a Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX
^b Institutional Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX
^c Department of Pediatrics Clinical and Experimental Immunology and Infectious Diseases, University of Texas Medical Branch, Galveston, TX
^d World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX

^⁎Address correspondence to William S. Lawrence, PhD, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555.Department of Microbiology & Immunology, University of Texas Medical BranchGalvestonTX77555

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Resumen

Efficient, rapid means of air decontamination are needed against widespread respiratory pathogens such as SARS-CoV-2, the virus that causes COVID-19. This study demonstrated the efficacy of advanced photohydrolysis technology in significantly reducing infectious, aerosolized SARS-CoV-2, achieving over 99% viral inactivation. Proof-of-concept assessments for respiratory syncytial virus and monkeypox virus showed similar results, suggesting broad applicability. These findings highlight the potential of the novel technology to enhance air purification and infection control strategies against multiple airborne viral pathogens.

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Highlights

•	Air decontamination is necessary to stop the spread of respiratory pathogens.
•	Photohydrolysis technology was previously shown to reduce bacterial loads.
•	Over 99% inactivation of aerosolized viral pathogens was achieved.

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Key Words : Air purification, Respiratory pathogens, Infection control, Viral aerosols

Esquema

	Funding/support: This research was supported by the World Reference Center for Emerging Viruses and Arboviruses, NIH grant R24 AI120942.
	Conflicts of interest: None to report.

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Vol 53 - N° 6

P. 726-728 - juin 2025 Regresar al número

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Advanced photohydrolysis technology demonstrates rapid inactivation of aerosolized SARS-CoV-2 and efficacy against other respiratory viral pathogens - 15/05/25

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