Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome affecting patients with signs and symptoms of heart failure with a normal or near normal left ventricular ejection fraction. The diagnosis of HFpEF can be challenging and often involves an extensive evaluation to rule out other conditions that might explain the symptom burden affecting patients. Clinical trials specifically targeting the management of HFpEF have been conducted, and clinical practice guidelines do exist although to a lesser degree in terms of the strength of recommendations as compared with other heart failure classifications.