Curcumin-loaded nanoemulsions and phloroglucinol target hexokinase 2 to inhibit Caveolin-1-induced glycolysis and metastasis in cancer cells - 20/07/25
, Keila Torres a, Simón Guerrero c, d, Felipe Oyarzun-Ampuero d, e, Andrew F.G. Quest b, d, ⁎ Abstract |
Metastasis, the dissemination of cancer cells, is promoted by metabolic reprogramming and the expression of Caveolin-1 (CAV1). Curcumin and phlorotannins have antioxidant and antitumoral activities. This study compares the potential anti-metastatic effects of phloroglucinol (phlorotannin monomer, PHG) and curcumin-loaded nanoemulsions (CUR-NEM) in CAV1-expressing cells. To that end, the metastatic cancer cell lines (MDA-MB-231 and B16-F10), which either express or not CAV-1, were treated with either PHG or CUR-NEM. The results demonstrate that PHG and CUR-NEM prevent cancer cell migration in vitro and metastasis in vivo of CAV1-expressing cells. Moreover, in the cancer cells treated with PHG or CUR-NEM, a significant reduction in glycolysis due to the inhibition of hexokinase activity was detected. These findings show that both PHG and CUR-NEM prevent metastasis in a preclinical animal model and link this ability to the inhibition of hexokinase 2, highlighting their potential significance as cancer therapeutics.
El texto completo de este artículo está disponible en PDF.Graphical Abstract |
Highlights |
• | Phloroglucinol (PHG) and curcumin-loaded nanoemulsions (CUR-NEM) prevent metastasis. |
• | PHG and CUR-NEM reduce glycolysis due to the inhibition of hexokinase activity. |
• | PHG and CUR-NEM have potential significance as cancer therapeutics. |
Abbreviations : CAV1, PHG, NEM, CUR-NEM, HK1 HK2 and HK3 respectively
Keywords : Bioactive natural compounds, polyphenol, curcumin, phlorotannin, glycolysis inhibitors, cancer metastasis
Esquema
Vol 189
Artículo 118339- août 2025 Regresar al número
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