Treatment of idiopathic inflammatory myopathies - 28/11/25

Highlights |
• | IVIG is FDA- and EMA-approved for refractory dermatomyositis and has demonstrated proven efficacy. |
• | Anti-synthetase syndrome often requires early aggressive immunosuppression to prevent ILD progression. |
• | JAK inhibitors, FcRN blockers, and CAR-T cell therapy show promise in myositis trials. |
• | IBM remains untreatable, but new trials are exploring sirolimus, ulviprubart and ruxolitinib. |
Abstract |
Adult idiopathic inflammatory myopathies (IIMs) are rare autoimmune disorders affecting multiple organs, making diagnosis and treatment challenging. Current management relies on immunosuppressants like corticosteroids, methotrexate, azathioprine, mycophenolate mofetil, rituximab, and intravenous immunoglobulin, though treatment responses vary across patients and subtypes. Despite substantial challenges in clinical research, such as patient recruitment, misdiagnoses from overlapping symptoms with other conditions, and inconsistencies in disease classification, the growing number of myositis-specific clinical trials provides optimism. Progress in targeted therapies has the potential to refine treatment approaches, support the development of more standardized, evidence-based guidelines, and ultimately enhance patient outcomes. In this paper, we aim to provide a review of the current therapeutic options based on IIM subtypes.
El texto completo de este artículo está disponible en PDF.Keywords : Dermatomyositis, Immune-mediated necrotizing myopathy, Anti-synthetase syndrome, Inclusion body myositis, Immunosuppressive therapy
Esquema
Vol 92 - N° 6
Artículo 105932- décembre 2025 Regresar al númeroBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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