An update on stroke and transient ischemic attack in Takayasu arteritis: A systematic review and meta-analysis - 08/01/26
Highlights |
• | The latest data show that the combined prevalence of stroke/TIA in TA patients is 10.7% (95%CI: 8.4%–13.6%). |
• | Contrary to traditional understanding, stroke/TIA is more likely to occur in male and European population. |
• | Smoking may be the only controllable risk factor for stroke /TIA in patients with TA. |
Abstract |
Objectives |
This systematic review and meta-analysis aimed to update the global prevalence of stroke and transient ischemic attack (TIA) in Takayasu arteritis (TA) patients, assess subgroup variations, and identify modifiable risk factors.
Methods |
Following PRISMA and MOOSE guidelines, eight databases (PubMed, EMBASE, Web of Science, Medline, and four Chinese databases) were systematically searched up to January 2025. A random-effects model was used to pool prevalence estimates, with subgroup analyses and risk factor evaluations. Heterogeneity was quantified using the I 2 statistic, and publication bias was assessed via funnel plots and Egger's test.
Results |
Thirty-four observational cohort studies (5112 patients involved) were included. The pooled prevalence of stroke/TIA in TA patients was 10.7% (95% CI: 8.4%–13.6%), with high heterogeneity (I 2 = 90.4%). Subgroup analyses revealed higher prevalence of stroke/TIA in males than in females (20% vs. 11%), and in European populations (13%). Ischemic stroke predominated (7%, I 2 = 80.7%), while hemorrhagic stroke was rare (2%, I 2 = 0%). Smoking was the sole significant modifiable risk factor (RR = 1.64, 95% CI: 1.13–2.38). Stroke accounted for 21.2% of all TA-related deaths.
Conclusions |
TA patients face a high burden of stroke/TIA, with marked heterogeneity driven by population and methodological differences. Males and Europeans have higher prevalence of stroke/TIA. Smoking is the only modifiable risk factor in TA patients with stroke/TIA.
El texto completo de este artículo está disponible en PDF.Keywords : Takayasu arteritis, Stroke, Transient ischemic attack, Systematic review, Meta-analysis
Esquema
Vol 93 - N° 1
Artículo 105951- janvier 2026 Regresar al número
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