Lessons from organoid engineering for rheumatic disease - 08/01/26
Highlights |
• | Organoids are emerging tridimensional culture models established from stem cells that aim to mimic organ structure and function. |
• | Organoid models are numerous, allowing promising applications: disease modelling, regenerative medicine and drug screening. |
• | The development of organoids is an alternative to animal experimentation, but raises newly scientific, technical and ethical challenges. |
• | This emerging tool offers promising prospects for the study of rheumatic diseases. |
Abstract |
Organoids are three-dimensional (3D) culture models developed from stem cells that aim to mimic both organ structure and functions. This technique is developing in the field of translational research, emerging as a key model through its multiple applications. Numerous models have been developed from various organs, allowing disease modelling, drug screening and hopes in regenerative medicine. First developments in the field of rheumatic diseases have been made notably in osteoarthritis, rheumatoid arthritis and Sjögren disease. In this review, we will focus on the establishment of organoid culture and the development and potential applications of 3D culture in rheumatic diseases.
El texto completo de este artículo está disponible en PDF.Keywords : Organoids, Rheumatic disease, Rheumatoid arthritis, Sjögren disease, Translational research.
Esquema
Vol 93 - N° 1
Artículo 105948- janvier 2026 Regresar al número
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