Time-course of health status in patients with rheumatoid arthritis during the first year of treatment with infliximab - 17/02/10
, Yutaka Furumitsu b, Keiji Okamoto a, b, Kazuhiko Yukioka b, Hitoshi Goto a, Yoshiki Nishizawa a
Corresponding author.Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 6 |
| Iconografías | 3 |
| Vídeos | 0 |
| Otros | 0 |
Abstract |
Objectives |
A longitudinal study was performed to examine changes in health status in comparison with rheumatoid arthritis (RA) inflammation in patients with RA during the first 54 weeks of infliximab (IFX) treatment.
Methods |
Health status in active RA patients (n=13) was assessed monthly using the Arthritis Impact Measurement Scale 2 (AIMS2) and the VAS-GH during the first year of IFX treatment. Simultaneously, RA activity was assessed using inflammation markers, MMP-3 and the Disease Activity Score in 28 joints (DAS-28) based on CRP [DAS-28(CRP)] and ESR[DAS-28(ESR)].
Results |
Serum CRP and ESR decreased significantly from 2.14±0.52mg/dL and 56.9±6.96mm/h, respectively, at baseline to 0.24±0.11mg/dL and 31.6±4.39mm/h, respectively, at 2 weeks after initiation of IFX. Other inflammatory markers and MMP-3 were also suppressed significantly after 2 weeks of IFX treatment. DAS-28(CRP) and DAS-28(ESR) were also significantly decreased after 2 weeks and suppression of both DAS values remained significant until 54 weeks of IFX treatment. After initiation of IFX, patient-reported general health also showed a significant improvement based on the changes in the six summary component scores on the AIMS2 (physical, affect, symptom, role, social interaction, and patient satisfaction). These scores all improved progressively until 14–18 weeks after initiation of IFX treatment, and then exhibited a temporary but insignificant exacerbation. The six components of the physical score also improved in a time-dependent manner until 14–18 weeks, but the scores for walking and bending, hand and finger function, arm function, self-care, and household tasks showed significant exacerbation at 22–30 weeks. The score for mobility level did not show this change.
Conclusion |
IFX treatment significantly improved both RA disease activity and health status in active RA patients. Time-dependent improvement of ADL until 14–18 weeks after initiation of IFX treatment, as reflected in the six components of the physical score, might have contributed to the temporary exacerbation of health status thereafter in these patients.
El texto completo de este artículo está disponible en PDF.Abbreviations : AIMS2, DAS, HAQ-DI, RA, TNF, VAS-GH, IFX
Keywords : Rheumatoid arthritis, Infliximab, QOL, AIMS2, DAS
Esquema
Vol 64 - N° 2
P. 107-112 - février 2010 Regresar al número
Artículo precedente
- Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis
- Hidefumi Kubo, Kanako Hosono, Tatsunori Suzuki, Yasufumi Ogawa, Hiroshi Kato, Hiroki Kamata, Yoshiya Ito, Hideki Amano, Tetsuki Kato, Hiroyuki Sakagami, Izumi Hayashi, Yukihiko Sugimoto, Shuh Narumiya, Masahiko Watanabe, Masataka Majima
- Thyroid blood flow as a useful predictor of relapse of Graves’ disease after normal delivery in patients with Graves’ disease
- Toshiki Nagasaki, Masaaki Inaba, Misako Fujiwara-Ueda, Junko Nishio, Yasuro Kumeda, Yoshikazu Hiura, Hideki Tahara, Eiji Ishimura, Osamu Ishiko, Yoshiki Nishizawa
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?