Association between cingulum bundle structure and cognitive performance: An observational study in major depression - 21/09/10
, A. Fellgiebel a, S. Wagner a, I. Yakushev a, P. Stoeter c, R. Schmitt e, R.J. Knickenberg d, F. Bleichner d, M.E. Beutel b
Corresponding author. Tel.: +49 0 6131 172488; fax: +49 0 6131 176690.Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
| páginas | 6 |
| Iconografías | 4 |
| Vídeos | 0 |
| Otros | 0 |
Abstract |
Background |
Major depression can be regarded as a systemic neurobehavioral disorder resulting from dysfunction of the limbic-cortical networks. The cingulum bundle represents a major association fiber tract of those networks. The aim of our study was to determine the association of brain structural tissue markers of the cingulum bundle and cognitive function in patients with major depression.
Methods |
Region-of-interest-based analyses of the middle-anterior and middle-posterior cingulum bundle fractional anisotropy (FA) and mean diffusivity (MD) using color-coded diffusion-tensor imaging and neuropsychological assessment in 14 patients with major depression.
Results |
FA of the middle-anterior and middle-posterior cingulum bundle was significantly correlated to the performance in a planning and divided attention task. Furthermore, MD of the middle-posterior cingulum bundle was significantly correlated to a planning task. There was no significant correlation between FA and MD of the cingulum bundle and selective attention or memory.
Conclusions |
Brain structural tissue markers of the middle-anterior and middle-posterior cingulum bundle were found to be associated with executive functioning and divided attention in patients with major depression. Disconnection within the limbic-cortical networks may underlay cognitive dysfunction in major depression.
El texto completo de este artículo está disponible en PDF.Keywords : Diffusion-tensor imaging, DTI, Cingulum bundle, Depression, Executive function
Esquema
Vol 25 - N° 6
P. 355-360 - octobre 2010 Regresar al número
Artículo precedente
- Brain imaging findings in children and adolescents with mental disorders: A cross-sectional review
- S. Mana, M.-L. Paillère Martinot, J.-L. Martinot
- Characteristic brain hypoperfusion by 99mTc-ECD single photon emission computed tomography (SPECT) in patients with the first-episode schizophrenia
- R. Wake, T. Miyaoka, K. Kawakami, K. Tsuchie, T. Inagaki, J. Horiguchi, Y. Yamamoto, T. Hayashi, H. Kitagaki
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
El acceso al texto completo de este artículo requiere una suscripción.
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
La compra de artículos no está disponible en este momento.
¿Ya suscrito a @@106933@@ revista ?