FC02-06 - Correlations between nucleus lentiformis asymmetry parameters (MRI data) and memory characteristics (semantic aspect) in patients with schizophrenia - 05/05/11
Resumen |
Introduction |
It’s evident that abnormalities of subcortical brain structures asymmetry are related with schizophrenia pathogenesis.
Objectives |
Basal ganglia participate in memory processes. Estimation of relationship between their asymmetry parameters and memory characteristics should be examined.
Aims |
To investigate correlations between nucleus lentiformis (NL) MRI parameters and memory peculiarities (semantic aspect) in schizophrenia 96 patients and 51 controls were examined.
Methods |
3D MR images were acquired on magnet 0.5 Tomikon S50, Bruker (69 patients‘and 34 controls‘groups) and 1.5T GE Signa System (27 patients‘and 17 controls‘groups). Volumes (V) of left and right NL and their asymmetry coefficients (2 x (right NLV- left NLV) x 100/ (right NLV+left NLV),%) were calculated.
Psychological pictogram method1,2 estimating mnestic activity including semantic aspect was used. Quantitative (retention productivity score (RPS) was analyzed.
Results |
Decreasing of the right (more prominent, p=0.046, p=0.044) and left NL (p=0.048, p=0.048) volumes were demonstrated in both patients groups. The RPS was less in both patients groups as compared with controls (p<0.01). Correlation between NL asymmetry coefficients and RPS was revealed in patients underwent 0.5 and 1.5T scanners (r=-0.51, p<0.05; r=- 0.57, p<0.05 correspondingly).
Conclusions |
The data confirm significance of brain asymmetry and memory dysfunction in etiology of schizophrenia.
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Vol 26 - N° S1
P. 1820 - 2011 Regresar al número
Artículo precedente
- FC02-05 - Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway
- B. Christensen, J. King, D. Westwood
- FC02-07 - Can darwinian theory help unlock the mystery of schizophrenia?
- R. Abed, M. Abbas
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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