Correlation between Serum Caffeine Levels and Changes in Cytokine Profile in a Cohort of Preterm Infants - 02/08/11
Abstract |
Objective |
To determine changes in cytokine levels associated with caffeine treatment in a cohort of preterm infants.
Study design |
For this observational prospective study, we collected clinical data from 26 preterm infants (≤30 weeks gestational age). In addition to caffeine levels, cytokine profiles in peripheral blood (PB) and tracheal aspirates (TA) were determined with enzyme-linked immunosorbent assay at birth, before and after (at 24 hours and 1 week) initiation of caffeine. Non-parametric statistics were applied.
Results |
Included infants were 26.9 ± 1.7 weeks gestational age and weighed 985 ± 202 g. At birth, all cytokine concentrations were significantly greater in TA than PB. Serum caffeine levels were 11.1 μg/mL (interquartile range, 1.85) at approximately 24 hours post-load and 16.4 (8.7) μg/mL at 1 week on treatment. At approximately 24 hours post-load, interleukin (IL)-10 levels decreased by 47.5% (P = .01) in PB and 38.5% (P = .03) in TA, whereas other cytokine levels remained unchanged. At 1 week, caffeine levels were correlated (U-shaped) with changes in proinflammatory tumor necrosis factor-⍺ (R2 = 0.65; P = .0008), interleukin (IL)-1β (R2 = 0.73; P = .0007), and IL-6 (R2 = 0.59; P = .003), whereas inversely correlated (linear) with the anti-inflammatory IL-10 (R2 = 0.64; P = .0008). Altogether, caffeine, at serum levels ≥20 μg/mL, was associated with a proinflammatory profile after 1 week of treatment.
Conclusions |
Caffeine treatment for apnea of prematurity correlates with changes in cytokine profile. Caffeine levels ≥20 μg/mL are associated with a proinflammatory profile in our cohort of preterm infants.
El texto completo de este artículo está disponible en PDF.Mots-clés : AR, BPD, BUN, cAMP, CBC, ETT, GA, GM-CSF, IL, INF, IQR, LLD, MV, PB, SNAP, TA, TNF
Esquema
| Supported by grants from Johns Hopkins University School of Medicine General Clinical Research Center (M01-RR00052), the National Center for Research Resources (NCRR)/The National Institutes of Health (NIH) (HL-072748 to E.B.G), Johns Hopkins University Institutional Research Grant, and the Thomas Wilson Sanitarium for Children of Baltimore City. The authors declare no conflicts of interest. |
Vol 158 - N° 1
P. 57 - janvier 2011 Regresar al número
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