Advanced MRI in Multiple Sclerosis: Current Status and Future Challenges - 06/08/11

Doi : 10.1016/j.ncl.2010.12.011

Robert J. Fox, MD ^a,^b,^⁎ , Erik Beall, PhD ^c, Pallab Bhattacharyya, PhD ^c, Jacqueline T. Chen, PhD ^d, Ken Sakaie, PhD ^c
^a Mellen Center for Multiple Sclerosis, Neurological Institute, 9500 Euclid Avenue, U-10, Cleveland, OH 44195, USA
^b Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
^c Mellen Imaging Center, Imaging Institute, Cleveland, OH, USA
^d Department of Neurosciences, NC30, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

Corresponding author. Mellen Center for Multiple Sclerosis, Neurological Institute, 9500 Euclid Avenue, U-10, Cleveland, OH 44195.

Resumen

MRI has rapidly become a leading research tool in the study of multiple sclerosis (MS). Conventional imaging is useful in diagnosis and management of the inflammatory stages of MS but has limitations in describing the degree of tissue injury and cause of progressive disability seen in later stages. Advanced MRI techniques hold promise for filling this void. These imaging tools hold great promise to increase understanding of MS pathogenesis and provide greater insight into the efficacy of new MS therapies.

El texto completo de este artículo está disponible en PDF.

Keywords : MRI, Imaging, Magnetization transfer imaging, Spectroscopy, Functional MRI, Diffusion tensor imaging