Right ventricular abnormalities in sickle cell anemia: Evidence of a progressive increase in pulmonary vascular resistance - 10/08/11
, James J. Joyce, MD, Ning Qi, MD, Ruey-Kang Chang, MD, MPH
Reprint requests: Dr. Naveen Qureshi, Children’s Hospital and Research Center at Oakland, Department of Pediatric Hematology/Oncology, 757 Fifty-Second Street, 2nd Floor, Oakland, CA 94609.Resumen |
Objective |
To assess the effects of sickle cell anemia (SCA) on the right ventricle (RV).
Study design |
Echocardiograms of 32 children with SCA were compared with age-matched healthy controls. RV measurements included diastolic area index, fractional area change, free-wall mass index, ejection time corrected for heart rate (ETc), and tricuspid regurgitation (TR) gradient.
Results |
SCA subjects had elevated RV ETc (mean ± standard deviation, 0.369 ± 0.030 sec vs 0.351 ± 0.022 sec; P < .01), diastolic area index (19.9 ± 2.4 cm2/m2 vs 13.2 ± 2.1 cm2/m2; P < .01) and free-wall mass index (33.2 ± 4.4 g/m2 vs 23.9 ± 4.3 g/m2; P < .01), whereas RV fractional area change (37 ± 8% vs 36 ± 4%) was not different from controls. Although RV diastolic area index in SCA paralleled the normal range over time, RV free-wall mass index continued to gradually rise throughout childhood (r = .42; P < .05). TR gradients > 2.5 m/sec, consistent with pulmonary hypertension, were found in 5 (16%) of SCA subjects, all older than 9 years.
Conclusions |
RV preload and systolic function do not worsen during childhood in SCA; however, RV mass index and the prevalence of pulmonary hypertension increase consistent with rising pulmonary vascular resistance.
El texto completo de este artículo está disponible en PDF.Abbreviations : BSA, ETc, RV, SCA, TR
Esquema
Vol 149 - N° 1
P. 23-27 - juillet 2006 Regresar al número
Artículo precedente
- 50 Years Ago in The Journal of Pediatrics : The incidence of abnormal blood levels of lead in a metropolitan pediatric clinic
- Kim N. Dietrich
- N-terminal pro-B–type natriuretic peptide levels in acute versus chronic left ventricular dysfunction
- Iris Fried, Benjamin Bar-Oz, Zeev Perles, Azaria J.J.T. Rein, Zeev Zonis, Amiram Nir
Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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