Pulmonary Sarcoidosis - 15/08/11

Doi : 10.1016/j.ccm.2008.03.002

Violeta Mihailovic-Vucinic, MD, PhD ^a,^b,^c,^⁎ , Dragana Jovanovic, MD, PhD ^a,^c
^a Medical School, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia
^b Yugoslav Association of Sarcoidosis, Visegradska 26/20, 11 000 Belgrade, Serbia
^c Vth Clinical Department, Institute of Pulmonary Diseases, University Clinical Center, Visegradska 26/20, 11 000 Belgrade, Serbia

Corresponding author. Vth Clinical Department, Institute of Pulmonary Diseases, University Clinical Center, Visegradska 26/20, 11 000 Belgrade, Serbia.

Abstract

Sarcoidosis is an inflammatory granulomatous disease that is characterized by diverse organ system manifestations, a variable clinical course, and a predilection for affecting relatively young adults worldwide. Abnormalities on chest radiographs are detected in 85% to 95% of patients who have sarcoidosis. Approximately 20% to 50% of patients who have sarcoidosis present with respiratory symptoms, including dyspnea, cough, chest pain, and tightness of the chest. The clinical course and manifestations of pulmonary sarcoidosis are protean: spontaneous remission occurs in approximately two thirds of patients; up to 30% of patients have chronic course of the lung disease, resulting in progressive, (sometimes life-threatening) loss of lung function. Morbidity that correlates to sarcoidosis occurs in 1% to 4% of patients.

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