The imaging evaluation of bone tumors in children is critical because it helps distinguish malignant (Figure 1 to Figure 9) from benign (Figure 10 to Figure 20) lesions and guides the subsequent evaluation, therapy, or observation of the patient. Most malignant bone tumors are present for months before diagnosis and their presence is easily detected on imaging. In most cases, malignant bone lesions should be referred to a regional center to have the proper imaging, biopsy, and surgery performed. Some benign lesions require only observation, whereas for others surgery or another local intervention is needed. All of the lesions illustrated in this article have undergone biopsy except two obvious benign lesions (see Figure 17 and Figure 19), which were simply observed.