Endoscopic full-thickness resection with sutured closure in a porcine model - 18/08/11
Reprint requests: Paul Swain, MD, Department of Surgical Oncology and Technology, St Mary's Hospital, 41 Willow Road, London NW3 1TN, UK.London, United Kingdom
Abstract |
Background |
Some early gastric cancers might be advantageously staged and treated by full-thickness resection if secure methods for closing the defect were available. The aim of this study was to test the feasibility of full-thickness gastric resection.
Methods |
Full-thickness gastric resections were performed by using a ligating device without submucosal injection in survival studies in pigs (n=8). The defects were closed by using new methods for suturing, locking, and cutting thread through a 2.8-mm accessory channel. Stitches (n=2-4) were placed close to the target area before resection.
Observations |
Full-thickness resections (n=8) were performed. The pigs survived without incident for 21 to 28 days. Healing of the suture site was evident at follow-up endoscopy. Suture sites were water tight. The pull-out force with stitches by using this new sewing method was significantly higher than with endoscopic clips (20.3 N ± 0.94 vs. 2.2 N ± 0.42, p < 0.05).
Conclusions |
Endoscopic full-thickness resection with sutured defect closure was feasible and appeared safe in these survival experiments.
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| This work was presented, in part, during Digestive Diseases Week, May 15-20, 2004, New Orleans, Louisiana (Gastrointest Endosc 2004;59:AB148). K. Ikeda received a research grant to study abroad from Jikei University, Tokyo, Japan. |
Vol 62 - N° 1
P. 122-129 - juillet 2005 Regresar al número
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