Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color - 19/08/11
, Susan Dowell, RN, PhD a, Mohammed Akhter, PhD a, Sowjanya Duthuluru, MD a, Christopher Huerter, MD a, Bruce W. Hollis, PhD b, Richard Lund, MD a, Robert P. Heaney, MD a
Correspondence to: Laura A. G. Armas, MD, Creighton University Medical Center, 601 North 30th St, Suite 4820, Omaha, NE 68131.Abstract |
Background |
Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized.
Objective |
We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation.
Methods |
Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly.
Results |
Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning.
Limitations |
Four weeks was not long enough to reach a steady state at the higher dose rates.
Conclusions |
The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.
El texto completo de este artículo está disponible en PDF.Abbreviations used : L, 25-OH-D, PTH, UV
Esquema
| Supported by Dialysis Clinics Inc, The Endocrine Fellows Foundation, and research funds of Creighton University. |
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| Disclosure: Dr Hollis is a consultant for Diasorin. Diasorin manufactures assays for 25-hydroxyvitamin D. Drs Armas, Dowell, Akhter, Duthuluru, Huerter, Lund, and Heaney have no conflicts of interest to declare. |
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| Reprints not available from the authors. |
Vol 57 - N° 4
P. 588-593 - octobre 2007 Regresar al número
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