An “apparent life-threatening event” (ALTE) refers to an episode that is of concern to the caregiver and is associated with a combination of apnea, color change, change in tone, choking, or gagging. Although the natural history of ALTE is most often benign, there is a risk for subsequent morbidity and mortality. The provider must stabilize the infant as needed, obtain key history, identify and address any underlying causes, educate the caregivers, and provide a safe disposition. This article summarizes the body of literature concerning ALTE, with specific attention to the diagnosis and management of these cases.