Colonization of residents of long-term care facilities with methicillin-resistant Staphylococcus aureus (MRSA) is an important healthcare concern. MRSA colonization is prevalent; in two of the most common sites of colonization, nares and wounds, colonization rates range from 8% to 53%, and 30% to 82%, respectively. With such a large number of patients harboring the organism, it is imperative that long-term care facilities are knowledgeable regarding the overall significance of MRSA, are aware of MRSA infection rates at their facilities, and have established a threshold above which outbreak precautions will be instituted. More importantly, facilities must ensure that appropriate precautions (e.g., hand washing, glove changes, gowns) are utilized to prevent transmission of MRSA to noncolonized residents. If these basic measures are taken, MRSA-colonized residents of long-term facilities should be able to be fully integrated into the everyday activities within the long-term care environment. In the event of an outbreak of MRSA infection, stricter isolation of colonized and infected residents is warranted, and such isolation should be discontinued as soon as the chain of transmission has been disrupted. Systemic antibiotics should be avoided in asymptomatic colonized patients; topical antibiotics like mupirocin should be reserved for short-term administration in outbreak situations.