PREMATURE OVARIAN FAILURE - 09/09/11
Resumen |
Premature ovarian failure is a condition characterized by amenorrhea, infertility, sex steroid deficiency, and elevated gonadotropins in women less than 40 years of age.71 It affects 1% of women by age 40 years and 0.1% by age 30 years.23 At one time, premature ovarian failure was considered irreversible and was described as premature menopause; however, young women with premature ovarian failure are now known to have intermittent ovarian function.70, 86
Early loss of ovarian function has significant psychosocial sequelae and major health implications. Women with premature ovarian failure have a nearly twofold age-specific increase in mortality rate107 and hence require thorough assessment, sex steroid replacement, and long-term surveillance to monitor therapy and minimize health risks in later life.
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| Address reprint requests to Lawrence M. Nelson, MD, Section on Women's Health, DEB, NICHD, National Institutes of Health, Building 10, Room 10N262, Bethesda, MD 20892–1862 SNK is the recipient of support by the D.B. Kaskarelis award from the Greek Obstetric and Gynecologic Society. |
Vol 27 - N° 4
P. 989-1006 - décembre 1998 Regresar al número
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- J. Lisa Tenover
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