DRUG-INDUCED HYPERTHERMIA - 10/09/11

Doi : 10.1016/S0749-0704(05)70369-9

Theodore C. Chan, MD ^{^{*
From the Department of Emergency Medicine and the Division of Medical Toxicology, University of California San Diego Medical Center, San Diego, California}}, Shawn D. Evans, MD ^{^{*
From the Department of Emergency Medicine and the Division of Medical Toxicology, University of California San Diego Medical Center, San Diego, California}}, Richard F. Clark, MD ^{^{*
From the Department of Emergency Medicine and the Division of Medical Toxicology, University of California San Diego Medical Center, San Diego, California}}

Resumen

Numerous homeostatic and regulatory control mechanisms act to balance body heat production and dissipation. Hyperthermia occurs when heat production exceeds the body's ability to lose heat or energy. Although the pathogenesis of hyperthermia varies among different etiologies, the complications are similar: rhabdomyolysis, disseminated intravascular coagulation, hyperkalemia, renal failure, metabolic acidosis, liver failure, and death. This article discusses four relatively common syndromes as examples of drug-induced hyperthermia: (1) familial malignant hyperthermia (MH), (2) neuroleptic malignant syndrome (NMS), (3) sympathomimetic poisoning, and (4) anticholinergic poisoning syndrome.

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Esquema

GENERAL PRINCIPLES OF HYPERTHERMIA

Thermal Homeostasis

General Mechanisms of Drug-Induced Hyperthermia

Consequences of Hyperthermia

General Treatment

DRUG-INDUCED HYPERTHERMIC SYNDROMES

NMS

Sympathomimetic Poisoning Syndrome

Anticholinergic Poisoning Syndrome

CONCLUSION

Address reprint requests to Theodore C. Chan, MD, Department of Emergency Medicine, UCSD Medical Center, 200 West Arbor Drive #8676, San Diego, CA 92103