GENETIC THERAPY : Past, Present, and Future - 11/09/11

Doi : 10.1016/S0031-3955(05)70468-5

Terence R. Flotte, MD ^{^{*
From the Departments of Pediatrics and Molecular Genetics and Microbiology; and the Gene Therapy Center, University of Florida School of Medicine, Gainesville, Florida (TRF); and the Division of Pediatric Pulmonology, Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Childrens Hospital, Cleveland, Ohio (TWF)}}, Thomas W. Ferkol, MD ^{^{*
From the Departments of Pediatrics and Molecular Genetics and Microbiology; and the Gene Therapy Center, University of Florida School of Medicine, Gainesville, Florida (TRF); and the Division of Pediatric Pulmonology, Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Childrens Hospital, Cleveland, Ohio (TWF)}}

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OVERVIEW OF GENETIC THERAPIES

Scope of Gene Transfer

Scope of Clinical Trials

VIRAL VECTORS

Moloney Murine Leukemia Virus

Lentiviruses

Adenovirus

Adeno-Associated Virus

Herpes Simplex Virus

NONVIRAL VECTORS

Receptor-Mediated Genetic Transfer

Liposome-Mediated Genetic Transfer

FUTURE DIRECTIONS

SUMMARY

Address reprint requests to Terence R. Flotte, MD, Departments of Pediatrics, and Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610–0266
The authors are supported in part by grants from the CF Foundation and the National Institutes of Health HL51811 (TRF), DK48996 (TWF), and DK27691 (TWF). Dr. Ferkol is also a co-founder of Copernicus Gene Systems, 11100 Cedar Avenue, Cleveland, Ohio.

Exportación

Vol 44 - N° 1

P. 153-178 - février 1997 Regresar al número

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GENETIC THERAPY : Past, Present, and Future - 11/09/11

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