Central Nervous System Complications After Transplantation - 25/10/11

Doi : 10.1016/j.ncl.2011.07.002

Rajat Dhar, MD, FRCPC(C) ^a,^⁎ , Theresa Human, PharmD, BCPS ^b
^a Division of Neurocritical Care, Department of Neurology, Washington University in St Louis School of Medicine, Campus Box 8111, 660 South Euclid Avenue, St Louis, MO 63110, USA
^b Neurology/Neurosurgery Intensive Care Unit, Department of Pharmacy, Barnes-Jewish Hospital, 216 South Kingshighway Boulevard, St Louis, MO 63110, USA

Corresponding author.

Resumen

The incidence of serious neurologic complications after organ and stem cell transplantation can be as high as 20% to 30%, with most occurring in the early posttransplant period. Encephalopathy often results from metabolic disturbances and immunosuppressant drug neurotoxicity but can also occur with central pontine myelinolysis and other lesions of the central nervous system (CNS). Seizures are also common and can be related to drug toxicity or herald CNS disorders. A thorough evaluation of any patient who develops seizures or mental status changes after transplantation is warranted to distinguish transient reversible causes from serious CNS disorders.

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Keywords : Organ transplantation, Bone marrow transplant, Seizures, Opportunistic infections, Brain diseases, Metabolic, Drug toxicity