Although arthrodesis is the treatment preferred by most surgeons for severe wrist arthritis, some degree of functional impairment occurs from the resulting loss of motion, especially when multiple joints in the extremity are affected by arthritis. Total wrist arthroplasty may enhance the performance of daily activities and it is usually preferred by patients over arthrodesis. The newer generation of wrist prostheses has demonstrated improved performance and durability in properly selected patients. This article provides a review of the history, indications, techniques, and outcomes of wrist arthroplasty.