Escitalopram is the most selective serotonin reuptake inhibitor used for treatment of major depressive disorder and generalized anxiety disorder. No available report indicating escitalopram may induce word finding difficulty. Here we are presenting a 50-year-old patient who suffered from escitalopram-induced word finding difficulty and the symptom resolved after replacing with bupropion. Carefully monitoring word finding difficulty and speech fluency during antidepressant treatment is important in clinical practice when using selective serotonin reuptake inhibitors, especially escitalopram.