Tumor necrosis factor alpha (TNF-⍺) inhibitors constitute a class of biologic treatments utilized in the management of psoriasis. We report a case of a patient treated for chronic plaque psoriasis with the anti-TNF-⍺ monoclonal antibody adalimumab, who developed erythema multiforme (EM). The patient had previously developed EM on two occasions while taking the TNF-⍺ inhibitor etanercept. EM has previously been reported in connection with other TNF-⍺ inhibitors, including etanercept and infliximab. To our knowledge, this is the first case reported in the literature documenting EM occurring subsequent to adalimumab treatment for psoriasis. The recurrent development of EM in our patient while being treated with distinct TNF-⍺ inhibitors may suggest that EM is the consequence of a class effect with TNF-⍺ inhibitors.