891 – Consanguinity multiplex and schizophrenia - the royal road to genes of major effect - 09/07/13
Resumen |
Introduction |
Multi-factorial aetiology of schizophrenia has an undeniably large genetic component. Attempts to elucidate its genetics with large case control studies have met with limited success and other approaches are warranted.
Method & results |
In an extended family (pedigree 1) in which two sets of siblings - children of a brother and sister - are intermarried; six members with DSM-IV schizophrenia share a 6MB region of homozygosity on chromosome 13q. One out of twelve genes at this locus shows a sequence change in its promoter region.
[Pedigree 1]
[Pedigree 1]
Another family (pedigree 2) with two affected brothers has revealed two loci of homozygosity on chromosomes 5 and 9.
[Pedigree 2]
[Pedigree 2]
A third family with nine cases of psychosis is being investigated.
Conclusion |
An approach which focuses on families with multiple cases in one generation and evidence of consanguinity in parents may be particularly successful for identifying recessive genes.
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Vol 28 - N° S1
P. 1 - 2013 Regresar al número
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