Low-Density Lipoprotein Cholesterol versus Particle Number in Middle School Children - 23/07/13
, James D. Otvos, PhD 3, Steven M. Willi, MD 4, Gary D. Foster, PhD 5, Russell Jago, PhD 6, John B. Buse, MD, PhD 7HEALTHY Study Group∗
Abstract |
Objectives |
To characterize lipids and lipoproteins in a diverse school-based cohort and identify features associated with discordance between low-density lipoprotein cholesterol (LDL-C) and LDL particle (LDL-P).
Study design |
Sixth-grade children enrolled in the HEALTHY trial (n = 2384; mean age 11.3 ± 0.6 years; 54.2% female) were evaluated for standard lipids, lipoprotein particles measured by nuclear magnetic resonance, and homeostatic model of insulin resistance. Characteristics of subgroups with values of LDL-C and LDL-P discordant by >20 percentile units, an amount reasoned to be clinically significant, were compared.
Results |
Four-hundred twenty-eight (18%) of children were in the LDL-P < LDL-C subgroup and 375 (16%) in the LDL-P > LDL-C subgroup. Those with LDL-P > LDL-C had significantly greater body mass index, waist circumference, homeostatic model of insulin resistance, triglycerides, systolic and diastolic blood pressure, and reflected a greater Hispanic ethnic composition but fewer of black race than both the concordant (LDL-P ≅ LDL-C) and opposite discordant (LDL-P < LDL-C) subgroups.
Conclusions |
There is as much lipoprotein cholesterol compositional heterogeneity in sixth graders as has been described in adults and a discordant atherogenic phenotype of LDL-P > LDL-C, common in obesity, is often missed when only LDL-C is considered. Conversely, many children with moderate-risk cholesterol measures (75th to 99th percentile) have a lower LDL-P burden.
El texto completo de este artículo está disponible en PDF.Keyword : apoB, BMI, CVD, HDL-C, HDL-P, HOMA-IR, LDL, LDL-C, LDL-P, NMR, TC, TG, VLDL, VLDL-P
Esquema
| Funded by the National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health (U01-DK61230, U01-DK61249, U01-DK61231, and U01-DK61223) and the American Diabetes Association. The authors declare no conflicts of interest. |
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| Registered with clinicaltrials.gov: NCT00458029. |
Vol 163 - N° 2
P. 355 - août 2013 Regresar al número
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