Individual and Composite Study Endpoints: Separating the Wheat from the Chaff - 22/04/14
, Joel M. Gore, MD c, Bruce Barton, PhD a, Jerry Gurwitz, MD b, cAbstract |
We provide an overview of the individual and combined clinical endpoints and patient-reported outcomes typically used in clinical trials and prospective epidemiological investigations. We discuss the strengths and limitations associated with the utilization of aggregated study endpoints and surrogate measures of important clinical endpoints and patient-centered outcomes. We hope that the points raised in this overview will lead to the collection of clinically rich, relevant, measurable, and cost-efficient study outcomes.
El texto completo de este artículo está disponible en PDF.Keywords : Clinical epidemiology, Study design, Study outcomes and endpoints
Esquema
| Funding: National Institutes of Health (RO1 HL35434). Partial salary support is provided to JMG and RG by National Institutes of Health grant 1U01HL105268. The development of this publication was partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under award number UL1TR000161 (BB). |
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| Conflict of Interest: None. |
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| Authorship: All authors had access to the data and a role in writing this manuscript. |
Vol 127 - N° 5
P. 379-384 - mai 2014 Regresar al número
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