Deep eutectic solvent-assisted one-pot synthesis of 2-aminothiazole and 2-aminoxazole derivatives - 16/06/15
, Zahra Rahimi, Masoumeh AlipourBienvenido a EM-consulte, la referencia de los profesionales de la salud.
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Graphical abstract |
Highlights |
• | A catalyst-free multicomponent reaction in DES is explored. |
• | Lost-cost, wide-scope and highly efficient substituted 2-aminothiazole and 2-aminoxazole were prepared. |
• | The method uses ecofriendly, green and efficient DES as a catalyst as well as a solvent. |
• | This protocol eliminates the use of hazardous organic solvents and toxic catalysts. |
Abstract |
Choline chloride–urea-based deep eutectic solvent (DES) has been found to be a highly effective catalyst and reaction medium for the one-pot synthesis of 2-aminothiazole and 2-aminoxazole derivatives. Three-component reactions of active methylene compounds, urea or thiourea and N-bromosuccinimide NBS in deep eutectic solvent furnished structurally diverse 2-aminoxazoles and 2-aminothiazoles in good to excellent yields under mild reaction conditions and short reaction times. DES is inexpensive, biodegradable and more accessible in any laboratory and industry.
El texto completo de este artículo está disponible en PDF.Keywords : 2-Aminothiazole, 2-Aminoazole, Deep eutectic solvent, Choline chloride, NBS
Esquema
Vol 18 - N° 6
P. 626-629 - juin 2015 Regresar al número
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Bienvenido a EM-consulte, la referencia de los profesionales de la salud.
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